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DeCS
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Descriptor English:
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Peroxisomal Multifunctional Protein-2
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Descriptor Spanish:
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Proteína-2 Multifuncional Peroxisomal
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Descriptor Portuguese:
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Proteína Multifuncional do Peroxissomo-2
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Synonyms English:
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17 beta Hydroxysteroid Dehydrogenase 4
17-beta-Hydroxysteroid Dehydrogenase 4
3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase
4, 17-beta-Hydroxysteroid Dehydrogenase
Dehydrogenase 4, 17-beta-Hydroxysteroid
Multifunctional Protein-2, Peroxisomal
Peroxisomal Multifunctional Enzyme Type 2
Peroxisomal Multifunctional Protein 2
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Tree Number:
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D08.811.520.241.300.275.500
D08.811.641.812
D08.811.682.047.436.375.640
D08.811.682.047.820.150.926
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Definition English:
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A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity. |
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History Note English:
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2014
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Allowable Qualifiers English:
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Record Number:
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55288
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Unique Identifier:
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D064029
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Occurrence in VHL:
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Similar:
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DeCS
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